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Targeted and non-targeted metabolomics analysis All sample preparation and instrumental analyses for targeted and non-targeted metabolomic analyses were conducted following the procedures outlined in our previous study 13 , with the exception of the analysis of tricarboxylic acid (TCA) metabolites, which were investigated using our validated in-house method

Structural Features MT-1 retains the 13-amino acid chain structure of -MSH Two substitutions within the structure of MT-1 increase its metabolic stability and half-life as compared to natural -MSH

Genital lesions, especially those occurring in the vulva, often show more prominent atypical features, such as moderate to severe cytologic atypia (epithelioid cells with prominent nucleoli) and occasional pagetoid spread

mTOR, Mechanistic Target of Rapamycin