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Future studies with larger sample sizes will be needed to validate these findings and to enable more detailed modeling of potential period and carry-over effects

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Disappointingly, similar studies performed in patients with PD have drawn inconsistent conclusions in which results from a small RCT did not show any significant improvement in the tamoxifen group compared with the placebo group (Teloken et al., 1999)

However, more randomized clinical trials that investigate the efficacy of vitamin C supplementation in migraine attacks are needed
