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By using a shRNA library covering the known metabolism-related enzymes and protein factors in the human genome, 3-hydroxy-3-methylglutaryl-CoA (HMGCL), the rate-limiting enzyme implicated in ketogenesis, is identified as a synthetic lethal partner of BRAF mutation in melanoma cells
This study is supported by the NIH/NIGMS R24 GM61374, The Personalized NSAID Therapeutics Consortium (PENTACON: HL117798) and by T32 H107971
Glutathione is the bodys most powerful antioxidant, helping combat harmful molecules that can come from diet, environmental sources, or normal bodily processes.* Liposomal technology delivers glutathione in extremely tiny phospholipid particles, allowing for fast absorption starting in the mouth
