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Improper storage causes irreversible peptide degradation: temperatures above 30C denature protein structure within 2 hours, freezing reconstituted peptides creates ice crystals that aggregate peptide molecules, and storing lyophilised vials in humid environments introduces moisture that hydrolyzes peptide bonds even before reconstitution

of Florence, 2 Fondazione Italiana Ricerca sulle Malattie dellOsso (F.I.R.M.O Onlus), 3 Stabilimento Chimico Farmaceutico Militare (SCFM)_Agenzia Industrie Difesa (AID), Florence, Italy Objective : Fibrous bone dysplasia (FBD) is a rare bone disease in which bone mineralization is altered

[DOI] [PubMed] [Google Scholar] 3.Reid LW, Elifson KW, Sterk CE

It has become a significant public health concern, with a global prevalence rate of 4.4% (Monroe and Harkness, 2022