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10.1371/journal.pone.0228568 PLoS One 116 RuffinM.MercierJ.CalmelC.MesineleJ.BigotJ.SutantoE

Moreover, it also shields cell membranes and blood vessels
Given the established role of immune dysfunction (including inflammatory cytokines, neuroinflammation, and immune cell abnormalities) in ME/CFS progression, the Low-dose Naltrexone for Post-COVID Fatigue Syndrome trial (NCT05430152) is currently exploring LDNs potential to reduce both fatigue and inflammation, thus providing a mechanistically grounded therapeutic approach

P., Chang, A., Markou, A