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In vivo and in vitro experiments clarify the hierarchical regulatory mechanisms: Butyrate directly regulates Th17/Treg homeostasis, promotes Treg differentiation through the HDAC1/FoxP3 pathway, and simultaneously inhibits Th17 activation and the expression of IL-17, IL-23, and RORt (89, 90)
Taken together, microglia initiate demyelination potentially through direct toxicity or the expression and secretion of cytokines (Fig
Apicella, M
