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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

Furthermore, calcium supplementation increased vitamin B12 levels in patients with T2D treated with metformin [35]

Adrenal fatigue responds best when people stop trying to push through exhaustion and instead start working with it

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