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Studies show that elevated TMAO decreases mTOR and p70S6K expression, causes hippocampal neuron loss and synaptic ultrastructural damage, and worsens cognitive function in mice, with higher TMAO leading to more severe deficits (Li et al., 2018)

diclofenac inhibits phorbol ester-induced gene expression and production of MUC5AC mucin via affecting degradation of IkB and translocation of NF-kB p65 in NCI-H292 cells

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Consistent supplementation, proper hydration, and correct timing all play essential roles in achieving these benefits effectively