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Manag Care 22:7172 Niessl C, Boulesteix AL, Oh J, Palm K, Schlingmann P, Wygoda S, Haffner D, Wuhl E, Tonshoff B, Buescher A, Billing H, Hoppe B, Zirngibl M, Kettwig M, Moeller K, Acham-Roschitz B, Arbeiter K, Bald M, Benz M, Galiano M, John-Kroegel U, Klaus G, Marx-Berger D, Moser K, Mueller D, Patzer L, Pohl M, Seitz B, Treikauskas U, von Vigier RO, Gahl WA, Hohenfellner K (2022) Relationship between age at initiation of cysteamine treatment, adherence with therapy, and glomerular kidney function in infantile nephropathic cystinosis

Studies have reported that the use of bisphosphonates can delay bone metastasis in patients with breast cancer and improve overall survival (36,37)

The main toxicity provoked is acute liver damage, which is mechanistically provoked by the aberrant adduction of the toxic metabolite N-acetyl p-benzoquinone imine (NAPQI) to cysteinyl residues of key liver proteins [105]