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For most people taking B12 at standard supplemental doses as part of a well-formulated multivitamin, this isn't a concern
Methionine serves as a methyl donor in numerous biochemical reactions and is a precursor to S-adenosylmethionine (SAMe), which participates in phospholipid synthesis
"2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society (in Eng)
it is not intended to replace the judgment and experience of the individual clinician faced with a particular patient
