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94 Although extremely promising, conversion of striatal astrocytes would not reproduce the nigrostriatal circuit, and conversion of nigral astrocytes would require coupling with an axonal pathfinding strategy as described above to elicit target connections to the striatum

It also decreased the expression of the PI3K/AKT/mTOR pathway and the NF-/TGF- pathway, inhibited CK18 and COX2 activity, increased the concentration of BAX and P53 proteins, and decreased Bcl-2, IL-6, IL-1, MMP2, and MMP9

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