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Secondly, since cardiomyocytes are easily affected by free iron overload, the release of excess free iron during ferroptosis would result in up-regulation of transferrin receptor (TFR) and down-regulation of ferritin, promoting cardiomyocyte cell death through mitochondrial VDAC2/3 or membrane lipid peroxidation through Fenton reaction to induce myocardial edema and dysfunction (Liu et al., 2018)

Metabolic analysis of the ceacal and plasma of the T2D mice demonstrated an increase in spermine and spermidine levels and their supplementation impeded the bone infection in the mice model [104]
Delivery kinetics and biodistribution were analyzed by administering nanoparticles loaded with the carbocyanine dye 1,10-Dioctadecyl-3,3,30,30-Tetramethylindotricarbocyanine Iodide (DiR) to healthy mice

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