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Comparative Mechanisms with Other Agents Compared with metformin, which improves insulin sensitivity primarily through hepatic and muscular pathways, GLP-1 RAs act centrally and peripherally to influence appetite, glucose metabolism, and systemic inflammation
The NRI (95% confidence interval) was 4.82% (1.877.77%)
While it reversed the declining trend in 2021, it still lags significantly behind Keytruda, with sales nearly half of the latter's
