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ALS pathology involves degeneration of upper and lower motor neurons, misfolded protein accumulation (e.g., TDP-43), mitochondrial dysfunction, oxidative stress, neuroinflammation, and excitotoxicity [100]

Molecular docking research has elucidated that apigenin-7-Oglucuronide presents a potent interaction with proteins related to lipid metabolism, including HMG-CoA reductase, PPAR , PPAR , PPAR and LPL

However, another randomized, double-blind, placebo-controlled trial in 181 patients with diabetic neuropathy found that oral supplementation with either 600 mg/day, 1,200 mg/day, or 1,800 mg/day of lipoic acid for five weeks significantly improved neuropathic symptoms (77)

Funding: Open Access publication was supported by an unrestricted donation from Pure Encapsulations, Sudbury, MA, USA