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Inclusion on the 503A Bulks List means the FDA has formally determined through rulemaking that a bulk drug substance may be used in compounding under Section 503A of the Federal Food, Drug, and Cosmetic Act

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To maximize the effects of statins with a short half-life, fluvastatin, lovastatin, and simvastatin should be dosed at bedtime allowing the greatest drug concentration to be present during peak endogenous cholesterol synthesis
