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For the research context it expanded the perspective from pure longevity to specific clinical indications , especially neurodegenerative diseases, where mitochondrial dysfunction and NAD+ deficit play a central role

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The mechanism behind the possible influence of B12 on the circadian rhythm is not clear, but there is evidence to suggest that B12 may increase the light sensitivity of the circadian clock

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High B12 is not usually dangerous on its own, but may point to issues like liver disease, kidney dysfunction, or blood cancers

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[14] In 1986, FDA substantially revised and expanded these cGMP regulations to better ensure the production of safe and sanitary foods

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