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Biological effects of Epitalon Dec 31, 2021 Epitalon is a synthetic peptide, telomerase activator, and putative anti-aging drug developed by the St

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To further investigate the transcriptional changes in functionally coordinated genes, Gene Set Enrichment Analysis (GSEA) 33 was performed using the Kyoto Encyclopedia of Genes and Genomes (KEGG) functional gene sets available in MSigDB ( The top 10 downregulated and 10 upregulated KEGG gene sets in GLA-mutant Fabry kidney organoids compared with WT kidney organoids are shown in Supplementary Table 2

However, control mice exhibited the expected 2DG-induced hyperphagia 22 , while this response was prevented in AgRP GHR KO mice (Fig