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Mol Pharmacol 45:237244 Kumar S, Samuel K, Subramanian R, Braun MP, Stearns RA, Chiu SH, Evans DC, Baillie TA (2002) Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide

FIGURE 5 FIGURE 6 Isotopic Tandem Orthogonal Proteolysis-Activity-Based Protein Profiling (isoTOP-ABPP) IsoTOP-ABPP was developed as an advanced approach to quantify/measure the reactivity of Cys residues directly in native biological samples