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[9] [10] [11] [12] Neurologically, magnesium acts to block the release of acetylcholine at the neuromuscular junction, thereby inhibiting peripheral neuromuscular transmission

Starting with acid breaks the hydrophobic interactions before the bulk solvent arrives, which is far more effective than adding water and trying to rescue a cloud afterward

Kakei, M., Yada, T., Nakagawa, A

The result is documented in the peer-reviewed obesity pharmacotherapy literature (PMC3136748) and represented a genuinely encouraging signal for an appetite-neutral compound with no stimulant mechanism
