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In contrast, glutamine catabolism also promotes ferroptosis induced by cysteine deprivation [41]
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Mechanistically, AgNPs induce cancer cell death via reactive oxygen species (ROS) generation, mitochondrial disruption, DNA damage, and interference with critical cell survival pathways such as PI3K/Akt, which collectively promote apoptosis and inhibit tumor proliferation (Palanisamy et al., 2025
