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MSU crystals induce inflammation by activating the complement system 3,4 , activation of myeloid cells leading to inflammatory cytokine production 5 , neutrophil activation 6 and NETosis 7,8 , and NLRP3 inflammasome activation 9

Reporting of the profile should include documentation of whether it was a fasting or non-fasting sample, details of which should be provided by the clinician at the time of the request, in addition to whether testing was requested in primary or secondary prevention to allow appropriate comments to be appended