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Besides, another study published in Chinese Medicine explored the effects of Cucurbitacin B on inhibiting transforming growth factor-beta 1 (TGF- 1)-induced epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC), revealing that Cucurbitacin B modulates ROS production and the phosphoinositide 3-kinase (PI3K)/AKT/ mammalian target of rapamycin (mTOR) signaling pathways [17]

In the MMR-D cohort, 12-month PFS was 63.5%, compared to 24.4% in the placebo arm, and 24-month PFS was 61.4%, compared to 15.7% in the placebo arm, HR 0.28 (95% CI 0.160.50)

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Metab Target Organ Damage 2021;1:3