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Calcium D-Glucarate is a specific form of calcium that assists the liver glucuronidation pathway by inhibiting the enzyme glucuronidase

The hypoxia alleviation via O2 production, the redox balance disruption via glutathione consumption and the reactive oxygen species generation, together would down-regulate the expression of O6-methylguanine-DNA methyltransferase under TMZ medication, which is considered as the key to drug resistance

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