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However, there is a huge difference in the therapeutic response to the two types of vitiligo
The classically activated macrophages M1 are in contact with high levels of Th1 cytokines (IFN-, IL-2, IL-12), proinflammatory cytokines (TNF, IL-1, IL-6, IL-18) and chemokines (MIP-1, MIP-1, RANTES) that favor the formation of viral reservoirs with strongly increased viral transcription and inhibition of HIV-1 entry to block superinfection within infected macrophages
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Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics
