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Glutaminase activity is enhanced 31-fold when an adenylated reaction intermediate is present in the SD, suggesting an interaction network that is present in NADSYN to prevent unproductive glutamine hydrolysis
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10.1038/sj.embor.7401062 EMBO Rep
This represents a milestone in immuno-oncology, successfully leading to standard clinical guideline updates, which established immunotherapy as a component of curative-intent treatment for early-stage disease
