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[DOI] [PubMed] [Google Scholar] 54

In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing

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They are crucial for collagen production and actively regulate collagen organization, ensuring proper alignment and strength of connective tissues
