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To partially compensate for this, patients are often given high systemic doses, which may increase brain exposure but also lead to significant off-target toxicity
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[DOI] [PubMed] [Google Scholar] Taherali F
The localization of FUNDC1 at ER-mitochondria contact sites (MAMs) and its role in integrating mitophagy, mitochondrial adaptation, and ER stress responses exemplify how spatial organization determines functional proteostasis outcomes
