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The development of neuronal senescence can be also linked to oxidative damage, as it was observed in rodents treated with DCTX (Moruno-Manchon et al., 2016)

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Translational limitations Although the phytochemical-mediated uPA/uPAR inhibition shows strong compelling in vitro and preclinical evidence, with a number of pharmacological challenges, there is limited translation of the inhibition into clinical benefit

Since the benefits of hydroxocobalamin over cyanocobalamin have become more apparent, the former has become the main substance used in B12 injections in Europe