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It all comes back to your research question

Sun Y, Zhang W, Li X
PTSD + MDD ( n = 18) and PTSD only ( n = 7) participants did not differ in circulating levels of MMP-9 ( p = 0.282), TIMP-1 ( p = 0.394), nor TIMP-2 ( p = 0.784)

Weekly dosing protocols are being investigated as alternatives
