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However, it was found to selectively induce apoptosis in human lymphoma cells, Daudi, Raji and Jurkat cells, by depleting the intracellular glutathione level rather than increase it

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Chac2 silencing led to a marked decrease in intracellular GSH content, accompanied by significantly reduced levels of proinflammatory cytokines, ROS production, NETs formation, and suppressed expression of N1 signature genes (Fig