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[PubMed] [Google Scholar] 154.Stewart AF, Rokosh DG, Bailey BA, Karns LR, Chang KC, Long CS, Kariya K and Simpson PC
Learn more Metabolic MOTS-c Mitochondrial peptide supporting cellular energy, metabolism, insulin sensitivity, and exercise performance
Subpockets A and B are also mostly hydrophobic and with only a few polar groups available to make polar interactions with the ligand
Luciferase reporter constructs containing this region confirmed its enhancer activity in K562 cells, and mutagenesis of the GATA1 binding sites resulted in significantly reduced enhancer activity
