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Thus, biosynthesis of 25(OH)VD and 1,25(OH) 2 VD and downstream actions of the VDR (VDR/PGC-1/GLUT4) are under the control of the VD regulatory genes (Figure 1)

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They demonstrate that urine SAM is a potent biomarker for monitoring renal function decline at early CKD stages [59]

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