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The specific consequences of AGE accumulation are not entirely understood but may alter both fiber and fibril behavior
doi:10.1161/CIRCULATIONAHA.122.062714 Redfors B, Stone GW, Alexander JH, et al
These findings also indicate that OPE may also implicate its protective effects in liver cells by promoting antioxidant capacity or either preventing formation of ROS (16)
Such decrease in levels is the result of diseases like exocrine pancreatic insufficiency
