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In some cases, a positive drug test could lead to disciplinary actions like suspension, termination, or restriction from engaging in some work tasks

The FDA guidance published in 1993 left the decision of including women of childbearing potential up to the researchers, IRBs, and women enrolling in the trial.34 In 1998, the FDA provided an updated guidance on the topic mandating sponsors to understand sex differences in PK, safety, and pharmacological response

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781 This adaptation involves not only localized proliferation and displacement but also significant reprogramming of cellular identity, with transient expression of fetal liver genes such as Afp , Cdh17 , and Spp1