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Moreover, it has been demonstrated that the quantity of NAD + in cluster I PCPGs was found to be 2.7-fold higher than that in cluster II PCPGs and elevated NAD + supports DNA repair pathway, resulting in DNA damage detoxification in SDHB-associated PCPGs [118]
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Discovery of bisubstrate inhibitors of nicotinamide N-methyltransferase (NNMT) J Med Chem
