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These drugs are known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function

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Buccione, R., Schroeder, A

It is thus of relevance to understand whether the metal core of metallothioneins can originate metal sulphide nano-crystals from the -elimination mechanism and whether these nano-crystals can play a role in the organ toxicity of accumulated metals, especially in the kidney
