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Caractersticas: Contiene L
A separate study demonstrated the presence of both pathways concurrently, finding that inhibition of intracellular trafficking increased LDLR levels without affecting extracellular PCSK9-mediated LDLR degradation (Poirier et al., 2009)
1, see Table 1 )
Furthermore, it may address pediatricians towards suitable individualized approaches, avoiding disproportionate treatments in cases with lethal neonatal forms, as well as reassuring families in those with milder adult-onset phenotypes and favorable evolution [48,49,50,51,52,53,54,55,56,57,58]
