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Mechanical load-induced H2S production by periodontal ligament stem cells activates M1 macrophages to promote bone remodeling and tooth movement via STAT1

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The lack of Piezo2 in sensory neurons accelerates gastric emptying and intestinal transport, and Piezo2 knockout mice exhibit diarrhea in bead-expulsion assays, suggesting that Piezo2 + sensory neurons are important factors involved in normal intestinal motility (110, 114)