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The goal of the 3R Principle is to avoid animal experiments altogether (Replacement) and to limit the number of animals (Reduction) and their suffering (Refinement) in tests to an absolute minimum
Additionally, two long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can be synthesized from ALA, but their synthesis may be insufficient under certain conditions, such as during pregnancy and lactation (87, 88)

Periodic follow-ups with your healthcare provider allow for adjustments to dosage and treatment plans based on your individual response and goals

As a parasite, Ascaris has developed several evasion mechanisms supported by molecular and cellular mechanisms including the secretion of immunomodulatory molecules including cystatins (8, 9)