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The finding that leptin deficiency in animals results in morbid obesity generated hope that exogenous administration of leptin would ameliorate obesity [11]
W., Volk, H., Caruso, D., Hironaka, L., Sices, L., et al
Both B12 shots and IV infusions bypass the gastrointestinal tract entirely, eliminating this dose-dependent absorption loss
However, at higher extracellular concentrations compared to intracellular concentrations, thiamine enters the cell by passive diffusion, so that exogenous thiamin supplementation remains effective even when SLC19A3 is dysfunctional
