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In addition, experimental studies were important in showing that MeHg is transported across the placenta from pregnant animals to their fetuses
Formation of protein adducts in hepatocytes impairs protein secretion, which has been proposed to play a role in enlargement of the liver (i.e., hepatomegaly)
All lines of evidence indicate that fast and slow TGR inhibitors bind different conformational states present in the TGR enzymatic cycle induced by both NADPH-dependent reduction and the concomitant destabilization of the polypeptide chain, as shown by TSA
