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Once released, deiodinase enzymes, including type I (D1) and type II (D2) enzymes, convert T4 into T3, which is the bioactive form of TH
Further experiments confirmed that miR-499-5p targets SOX6 , a specific factor known to inhibit the expression of slow-twitch muscle genes, and miR-196-5p targets CALM1 , a key element in the cGMP-PKG and calcium signaling pathways
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Abd-Elhakim YM, et al
