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These mutations include gain-of-function mutations of the MC2R, GNAS, the catalytic subunit of protein kinase A (PRKACA) and PRKACB genes and inactivating mutations of the regulatory subunit R1 of PKA ( PRKAR1A ), and of two cAMP-binding phosphodiesterases ( PDE11A and PDE8B ) genes, mimicking the action of ACTH to stimulate glucocorticoid production, providing a molecular basis for the pathogenesis of primary adrenal Cushing syndrome (22)

Butler M, et al

1 Moreover, it has been reported that diets high in MUFA are associated with a reduced mortality by cardiovascular disease