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Specifically, cargo adaptor proteins, ADP ribosylation factors (Arfs), coat proteins, and accessory proteins are essential for sorting cargo at the TGN [64, 66]

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Epigenetic regulation of ageing: linking environmental inputs to genomic stability

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In the pre-specified week-72 analysis of part 1, 62.9% of semaglutide-treated participants achieved resolution of steatohepatitis without worsening of fibrosis versus 34.3% with placebo (estimated difference ~28.7 percentage points), and unlike the earlier phase 2 36.8% achieved improvement in liver fibrosis without worsening of steatohepatitis versus 22.4% with placebo (estimated difference ~14.4 points

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