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Inhibition of this pathway under normal conditions phenocopied a hyperglycemic state by enhancing chemotherapeutic efficacy in mouse PDAC, while rescuing the pathway under high glucose abrogated the anti-tumor effects observed with chemotherapy
Ottaviano FG, Handy DE, Loscalzo J (2008) Redox regulation in the extracellular environment
Furthermore, immediately reacts with to generate cytotoxic peroxynitrite (ONOO ) and this reaction itself has several consequences
