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External factors such as the acidification and inflammatory of the tumor microenvironment (TME) could also affect cholesterol metabolism

Recent studies have revealed that the NLRP3 inflammasome is activated in the brain to induce neuroinflammation, leading to further neuronal damage and functional impairment, and contributes to the pathological process of various neurological diseases, such as multiple sclerosis, Parkinsons disease, Alzheimers disease, and stroke

It has been proposed that heightened chemoreflex gain may contribute to SA by destabilizing central respiratory network control of airway tone and/or ventilation ( In this application, loop gain can be thought of as the ratio of the size of a response (change in ventilation) to the size of a disturbance (change in PaCO 2 )