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This is one of the most important long-term risks of these medications and is directly addressed by intentional protein timing

[DOI] [PubMed] [Google Scholar] Lee SR, Yang KS, Kwon J, Lee C, Jeong W, Rhee SG

In this regard, it is noteworthy that calorie restriction is associated with increased longevity and reduced insulin/IGF activity in many species (81) albeit GH levels are increased by calorie restriction and fasting (82)

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