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Alteration in iron metabolism during retinal degeneration in rd10 mouse

Hernndez et al., 2017)

Shikonin effectively blocked the IKK/IKK complex formation in vitro and in vivo via preventing the IKK-binding domain (NBD) of IKK from entering the hydrophobic pocket of IKK ( Figure 3 ), resulting the inhibition of proliferation, migration, and invasiveness [60]

This allows for reactions with a broad spectrum of both physiological metabolites (such as estrogen, prostaglandins, and leukotrienes) and xenobiotics (including acetaminophen, persistent organic pollutants, and toxic metals such as mercury, arsenic, and lead)