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A large phase 3 clinical study of 1,380 nondiabetic participants showed that 8 weeks of berberine increased high-density lipoprotein (HDL) cholesterol and reduced diastolic blood pressure, waist girth, triglycerides, total and non-HDL cholesterol, and risk of metabolic syndrome
It is assumed that the persistent autoimmune stimulation in the course of active RA gives a boost to the production of IgG4 (60, 61)
