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The supernatant S1 and pellet P1 were collected

A study suggested that in GCH1-deficient mice, BH4 could still accumulate with age, which was associated with the production of BH4 by specific gut microbiota, such as intestinal Actinobacteria [118]

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Mechanistic studies revealed that the expression of iron regulatory protein 2 (IRP2), a key regulator of iron homeostasis, is downregulated in age-related cataracts, leading to abnormally elevated free iron levels in the lens ( Furthermore, research has found that the aging process in the lens is accompanied by a decline in autophagic function ( The findings from studies on ferroptosis in age-related cataracts provide valuable insights into the potential role of ferroptosis in radiation-induced cataracts, as both types share common pathogenic factors such as oxidative stress and lipid peroxidation